Antiviral Potential of Surface Coatings HCoV-229E & SARS-CoV-2

By: Nayla Chapa 

HCoV-229E (blue) and SARS-CoV-2 (grey) noncoated surfaces represent (solid bards) coated surfaces (dashed lines) this includes rounds of 1,7, 30, and 90 upon cleaning using a water-based detergent and microfiber cloth. Letter A is copper compound and B is QAC. Figure taken from Butot et al. 2021.

SARS-CoV-2 also known as Covid-19 spreads from individual to individual through respiratory droplets. Both SARS-CoV-2 and HCoV-229E are known to stay on high-touch surfaces for periods. Therefore researchers will be testing to see how reactive oxygen species, copper compounds, and quaternary ammonia compounds (QAC) do in terms of the antiviral effects in high touch surfaces immediately, after cleaning coated surfaces, and antiviral activity when organic compounds are present. Copper compounds did well in all three while QAC wasn't able to meet the second and lastly reactive oxygen species seemed to show no antiviral effect. In the figure, we see how they only included copper compounds and QAC when not being cleaned and when being cleaned with a microfiber cloth for both viruses. The copper compound was able to withstand large rounds of cleaning while QAC was wiped down on its first round. Overall this is useful since we are able to know that QAC isn't very effective in comparison to copper compounds that if one is to clean the surface it can hold at least 90 rounds. Essentially more research should be done to see why reactive oxygen species don't do too well in antiviral effects if their pH affects their temperature or anything else.

Refrence:

Butoto, S., Baert, L., & Zuber, S. (2021). Assessment of Antiviral Coatings for High-Touch Surfaces by Using Human Coronaviruses HCoV-229E and SARS-CoV-2. Applied and Environmental Microbiology, 87(19), e0109821 doi:10.1128/AEM.01098-21